Negative regulation of reactive oxygen species metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of reactive oxygen species metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G6PD, SSB, and RPE, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of reactive oxygen species metabolic process activity versus G6PD in LUNG_NSCLC_LUSC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	G6PD →	+2.796	+0.336	.008	.001	3	7
OESOPHAGUS	SSB →	+0.593	+0.174	.002	.008	3	5
UPPER_AERODIGESTIVE_TRACT	RPE →	+0.958	+0.242	.004	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	TXNRD1 →	+1.754	+0.264	.005	.003	3	5
BREAST	OLA1 →	+0.641	+0.168	.004	.002	3	5
OVARY	TSPAN10 →	-1.248	-0.294	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000378 vs G6PD — LUNG_NSCLC_LUSC

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