Regulation of reactive oxygen species metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of reactive oxygen species metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NXT1, SET, and TRAF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NXT1 grouped by Regulation of reactive oxygen species metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NXT1 →	+0.839	+0.312	.003	<.001	3	4
LUNG_NSCLC_LUAD	SET →	+0.646	+0.138	.003	<.001	3	4
SOFT_TISSUE	TRAF2 →	+0.700	+0.283	.003	.001	3	3
STOMACH	NUP93 →	+0.833	+0.220	.001	.001	2	4
SOFT_TISSUE	ACTA2 →	-3.953	-0.285	.002	.001	3	3
BLOOD_Lymphoma	STYXL1 →	+1.239	+0.339	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NXT1 by Regulation of reactive oxygen species metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →