Regulation of clathrin-dependent endocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of clathrin-dependent endocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RTN1, EVL, and KDM1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of clathrin-dependent endocytosis activity versus RTN1 in CCRCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RTN1 →	+0.580	+0.049	<.001	<.001	3	5
BRCA	EVL →	+0.361	+0.020	.002	.002	3	5
LSCC	KDM1A →	-0.269	-0.053	.002	<.001	3	5
GBM	INPP4A →	+0.151	+0.044	<.001	<.001	3	5
GBM	METTL1 →	-0.422	-0.064	.001	<.001	3	5
LUAD	NEFL_S472 →	+0.904	+0.036	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000369 vs RTN1 — CCRCC

Explore this scatter interactively →