Regulation of clathrin-dependent endocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of clathrin-dependent endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPGDS, MS4A7, and CDC6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of clathrin-dependent endocytosis activity versus HPGDS in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HPGDS →	+0.431	+0.122	.001	.006	3	6
LSCC	MS4A7 →	+0.851	+0.170	<.001	<.001	3	6
PDAC	CDC6 →	-0.772	-0.455	<.001	<.001	3	6
LSCC	TTK →	-0.821	-0.160	<.001	<.001	3	5
LSCC	KIF18A →	-0.649	-0.174	<.001	<.001	3	5
LSCC	SKA1 →	-1.273	-0.240	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000369 vs HPGDS — LSCC

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