Regulation of clathrin-dependent endocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of clathrin-dependent endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARIH2, EIF5A, and CIBAR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARIH2 grouped by Regulation of clathrin-dependent endocytosis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ARIH2 →	-0.509	-1.229	<.001	<.001	3	5
OVARY	EIF5A →	-0.602	-0.638	.002	.003	3	4
LUNG_NSCLC_LUAD	CIBAR1 →	-1.150	-0.675	.002	.005	2	5
LUNG_SCLC	ARIH2OS →	-0.720	-1.052	.002	.004	3	4
OVARY	BLOC1S6 →	-0.709	-0.712	<.001	<.001	3	3
OVARY	GDF15 →	+3.054	+0.794	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARIH2 by Regulation of clathrin-dependent endocytosis activity — CNS

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