Regulation of binding of sperm to zona pellucida

Across TCGA patient cohorts, RNA activity of the Regulation of binding of sperm to zona pellucida pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBRG4, AIFM1, and MRPL41, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of binding of sperm to zona pellucida activity versus TBRG4 in COAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TBRG4 →	+0.498	+0.146	<.001	<.001	3	5
COAD	AIFM1 →	+0.315	+0.086	<.001	<.001	3	5
COAD	MRPL41 →	+0.314	+0.101	<.001	<.001	3	5
COAD	OCIAD1 →	+0.217	+0.092	<.001	<.001	3	5
COAD	PPA2 →	+0.356	+0.113	<.001	<.001	3	5
OV	SLC30A9 →	+0.237	+0.074	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000359 vs TBRG4 — COAD

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