Regulation of binding of sperm to zona pellucida

Across TCGA cell cohorts, RNA activity of the Regulation of binding of sperm to zona pellucida pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD4, GTPBP10, and FUNDC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD4 grouped by Regulation of binding of sperm to zona pellucida-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CD4 →	-0.098	-1.309	.004	<.001	3	4
LUNG_NSCLC_LUAD	GTPBP10 →	+0.150	+1.023	.002	.003	2	5
STOMACH	FUNDC2 →	-0.099	-1.494	.001	.001	3	4
BLOOD_Myeloma	SNCG →	-0.285	-2.205	.005	.003	3	3
BONE	KIAA1549L →	+0.337	+2.301	.001	<.001	3	3
BONE	SRSF11 →	+0.390	+1.742	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD4 by Regulation of binding of sperm to zona pellucida activity — OESOPHAGUS

Explore this box plot interactively →