Regulation of ovarian follicle development

Across TCGA cell cohorts, RNA activity of the Regulation of ovarian follicle development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMH, TAOK2, and EXOC8, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ovarian follicle development activity versus AMH in LUNG_NSCLC_LUSC (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AMH →	-2.175	-0.123	<.001	<.001	3	14
BREAST	TAOK2 →	-0.983	-0.095	.004	.001	3	7
BLOOD_Lymphoma	EXOC8 →	-0.489	-0.065	.005	.006	3	7
BLOOD_Leukemia	CNOT6 →	-0.530	-0.127	<.001	<.001	3	7
BLOOD_Leukemia	KDM3B →	-0.528	-0.154	<.001	<.001	3	7
BREAST	GLI4 →	-1.099	-0.088	.002	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000354 vs AMH — LUNG_NSCLC_LUSC

Explore this scatter interactively →