Positive regulation of endothelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of endothelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AXL, BTG2, and NNMT, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AXL grouped by Positive regulation of endothelial cell apoptotic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AXL →	+2.800	+0.954	<.001	<.001	3	7
SOFT_TISSUE	BTG2 →	-1.844	-1.305	.005	.002	2	7
SOFT_TISSUE	NNMT →	+4.835	+1.414	.003	.004	3	6
OVARY	RHEBL1 →	+1.087	+1.161	<.001	<.001	3	6
BREAST	FXYD5 →	+2.452	+0.701	.006	.002	3	6
CNS	MDM2 →	-1.211	-0.676	.005	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AXL by Positive regulation of endothelial cell apoptotic process activity — BREAST

Explore this box plot interactively →