Positive regulation of endothelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of endothelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-C, PSMB9, and IRF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell apoptotic process activity versus HLA-C in STOMACH (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HLA-C →	+2.273	+1.392	.001	.005	2	8
STOMACH	PSMB9 →	+2.813	+1.483	<.001	.004	3	7
SKIN	IRF1 →	+1.516	+0.710	.002	.006	3	6
PANCREAS	ARHGDIB →	+3.108	+1.098	.006	.005	3	6
STOMACH	KCNN4 →	+4.208	+1.350	<.001	.005	3	6
OVARY	JPH2 →	+1.684	+1.335	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000353 vs HLA-C — STOMACH

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