Regulation of CD40 signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of CD40 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP36_S73, BAZ1B_S349, and DNMT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of CD40 signaling pathway activity versus RRP36_S73 in LUAD (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RRP36_S73 →	+0.834	+0.057	<.001	<.001	3	8
BRCA	BAZ1B_S349 →	+0.870	+0.045	<.001	<.001	3	8
UCEC	DNMT1 →	+0.376	+0.111	<.001	<.001	3	8
BRCA	DNMT1_S714 →	+0.576	+0.056	<.001	<.001	3	8
HNSC	LIG1_S76 →	+0.857	+0.081	<.001	.001	3	8
BRCA	MKI67 →	+0.779	+0.058	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000348 vs RRP36_S73 — LUAD

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