Regulation of CD40 signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of CD40 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XRRA1, ZBTB25, and CWC25, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XRRA1 grouped by Regulation of CD40 signaling pathway-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	XRRA1 →	-1.141	-1.256	.008	.002	3	4
UPPER_AERODIGESTIVE_TRACT	ZBTB25 →	-1.182	-1.494	.003	.006	3	4
OVARY	CWC25 →	-0.730	-0.820	<.001	.001	3	4
SOFT_TISSUE	GJA3 →	+1.318	+1.023	.001	.009	3	4
LUNG_NSCLC_LUAD	SLC12A9 →	+0.758	+0.957	<.001	.003	3	4
LIVER	FRA10AC1 →	-1.084	-1.749	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XRRA1 by Regulation of CD40 signaling pathway activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →