Positive regulation of hepatocyte proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of hepatocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF703, WFS1, and BLOC1S3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hepatocyte proliferation activity versus ZNF703 in HNSC (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF703 →	+0.891	+0.151	.001	<.001	3	4
BRCA	WFS1 →	+0.798	+0.559	<.001	.002	3	3
BRCA	BLOC1S3 →	+0.265	+0.535	.003	.001	3	3
UCEC	MZT1 →	+0.412	+0.663	.007	<.001	3	3
LUAD	IDI2 →	+0.106	+0.472	.006	.003	3	3
HNSC	ATP6V0E2 →	+0.756	+0.164	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000347 vs ZNF703 — HNSC

Explore this scatter interactively →