Positive regulation of hepatocyte proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of hepatocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHTF8, REEP1, and THAP11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHTF8 grouped by Positive regulation of hepatocyte proliferation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CHTF8 →	+0.721	+1.037	.003	.007	3	5
OESOPHAGUS	REEP1 →	-1.530	-1.378	.004	.003	3	4
LUNG_NSCLC_LUSC	THAP11 →	+0.744	+1.254	.003	.003	3	4
SKIN	SORL1 →	-1.445	-1.042	.007	.002	2	5
SKIN	ERAP2 →	+1.594	+0.835	<.001	.003	3	4
URINARY_TRACT	WDR53 →	+0.448	+0.241	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHTF8 by Positive regulation of hepatocyte proliferation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →