Regulation of hepatocyte proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of hepatocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENPP4, MAP3K2, and ST6GAL1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hepatocyte proliferation activity versus ENPP4 in LARGE_INTESTINE (Pearson r = -0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ENPP4 →	-1.063	-0.477	.005	<.001	3	2
LARGE_INTESTINE	MAP3K2 →	+0.613	+0.444	.004	<.001	3	2
LARGE_INTESTINE	ST6GAL1 →	-3.900	-0.477	<.001	<.001	3	2
LUNG_NSCLC_LUAD	TSHR →	-0.146	-0.262	<.001	.008	3	1
PANCREAS	COP1 →	+0.515	+0.415	.008	.007	3	1
PANCREAS	MYLK4 →	+0.818	+0.372	.001	.009	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000345 vs ENPP4 — LARGE_INTESTINE

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