Positive regulation of acrosome reaction

Across TCGA patient cohorts, RNA activity of the Positive regulation of acrosome reaction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP1, RAB8B, and PTPRC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of acrosome reaction activity versus GBP1 in BRCA (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBP1 →	-0.648	-0.048	<.001	.001	3	6
PDAC	RAB8B →	-0.292	-0.062	.005	.001	3	5
PDAC	PTPRC →	-0.371	-0.050	.002	.001	3	5
BRCA	DLG5 →	+0.277	+0.051	.008	.002	3	4
BRCA	GSTM3 →	+1.118	+0.055	<.001	.002	3	4
BRCA	KRT8_S253 →	+0.826	+0.056	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000344 vs GBP1 — BRCA

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