Positive regulation of acrosome reaction

Across TCGA patient cohorts, RNA activity of the Positive regulation of acrosome reaction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM25E, TRPC5, and MYBL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of acrosome reaction activity versus FAM25E in BRCA (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM25E →	+0.730	+0.166	.004	<.001	3	4
GBM	TRPC5 →	+0.449	+0.585	.001	.003	3	4
UCEC	MYBL1 →	-0.566	-0.987	.001	.003	3	3
BRCA	SRGAP3-AS3 →	+0.105	+0.147	<.001	<.001	3	3
GBM	RUNDC3A →	+1.169	+0.723	<.001	<.001	3	3
GBM	SPART-AS1 →	+0.522	+0.732	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000344 vs FAM25E — BRCA

Explore this scatter interactively →