Negative regulation of chemokine (C-X-C motif) ligand 2 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of chemokine (C-X-C motif) ligand 2 production pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ICE1_S533, OAS3, and OAS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemokine (C-X-C motif) ligand 2 production activity versus ICE1_S533 in COAD (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ICE1_S533 →	-0.343	-0.034	<.001	<.001	3	6
GBM	OAS3 →	+0.730	+0.081	<.001	.009	3	6
GBM	OAS2 →	+1.138	+0.122	<.001	<.001	3	5
OV	STAMBP_S247 →	+1.864	+0.150	<.001	.004	3	4
OV	GRAMD1A_S267 →	-0.611	-0.060	.005	.003	3	4
OV	PLSCR1 →	+0.591	+0.060	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000342 vs ICE1_S533 — COAD

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