Negative regulation of chemokine (C-X-C motif) ligand 2 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemokine (C-X-C motif) ligand 2 production pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF4, CCK, and OAS3, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF4 grouped by Negative regulation of chemokine (C-X-C motif) ligand 2 production-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KLF4 →	-0.556	-1.800	<.001	<.001	3	16
OESOPHAGUS	CCK →	-0.655	-1.788	<.001	<.001	3	9
KIDNEY	OAS3 →	-0.288	-1.139	<.001	.001	3	8
LARGE_INTESTINE	OAS1 →	-0.125	-0.826	.002	.003	3	8
BLOOD_Leukemia	HTR5A →	-0.220	-1.094	.005	.007	2	7
LUNG_NSCLC_LUSC	RACGAP1 →	-0.493	-1.183	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF4 by Negative regulation of chemokine (C-X-C motif) ligand 2 production activity — LUNG_SCLC

Explore this box plot interactively →