Negative regulation of chemokine (C-X-C motif) ligand 2 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemokine (C-X-C motif) ligand 2 production pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFC5, WDR19, and ARRDC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RFC5 grouped by Negative regulation of chemokine (C-X-C motif) ligand 2 production-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RFC5 →	-1.043	-1.459	.009	.002	3	4
BONE	WDR19 →	-1.465	-1.710	.002	<.001	3	4
BLOOD_Lymphoma	ARRDC4 →	+2.029	+1.927	<.001	<.001	3	4
BLOOD_Lymphoma	ZKSCAN3 →	-0.634	-1.624	.006	.002	3	4
CNS	GSTCD →	-0.490	-1.201	.001	<.001	3	4
LIVER	SESN1 →	+1.520	+1.267	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RFC5 by Negative regulation of chemokine (C-X-C motif) ligand 2 production activity — BONE

Explore this box plot interactively →