Positive regulation of chemokine (C-X-C motif) ligand 1 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of chemokine (C-X-C motif) ligand 1 production pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP25, GCHFR, and BIRC6_S480, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chemokine (C-X-C motif) ligand 1 production activity versus UTP25 in BRCA (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UTP25 →	-0.294	-0.056	<.001	<.001	3	4
GBM	GCHFR →	+0.745	+0.076	<.001	.001	3	4
GBM	BIRC6_S480 →	+0.409	+0.062	.002	.009	3	4
HNSC	COG3 →	+0.176	+0.066	.001	.004	3	4
GBM	DGCR8_S35 →	+0.620	+0.115	<.001	<.001	3	4
GBM	MPRIP_S993 →	+0.291	+0.051	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000340 vs UTP25 — BRCA

Explore this scatter interactively →