Positive regulation of chemokine (C-X-C motif) ligand 1 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of chemokine (C-X-C motif) ligand 1 production pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INTS3, REXO1, and DHRS4L2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INTS3 grouped by Positive regulation of chemokine (C-X-C motif) ligand 1 production-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	INTS3 →	-0.642	-1.351	<.001	<.001	3	4
KIDNEY	REXO1 →	-0.674	-0.620	.006	.007	3	4
LIVER	DHRS4L2 →	-0.657	-0.291	.005	.001	3	3
BLOOD_Lymphoma	VPS13D →	+0.557	+0.380	.001	.001	3	3
BREAST	PASK →	-0.958	-0.991	.006	.001	3	3
BREAST	NBPF20 →	-0.767	-0.992	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INTS3 by Positive regulation of chemokine (C-X-C motif) ligand 1 production activity — SKIN

Explore this box plot interactively →