Positive regulation of chemokine (C-X-C motif) ligand 1 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of chemokine (C-X-C motif) ligand 1 production pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC26A1, MXD1, and KCNK10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC26A1 grouped by Positive regulation of chemokine (C-X-C motif) ligand 1 production-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC26A1 →	+0.545	+1.760	.006	<.001	2	5
CNS	MXD1 →	+0.166	+0.864	.005	.001	3	4
SOFT_TISSUE	KCNK10 →	+0.241	+1.180	.004	.005	3	3
LUNG_SCLC	CST3 →	+0.220	+1.277	.003	.006	3	3
SOFT_TISSUE	MIR205HG →	+0.303	+1.872	.008	<.001	3	3
SOFT_TISSUE	BIRC5 →	+0.489	+1.335	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC26A1 by Positive regulation of chemokine (C-X-C motif) ligand 1 production activity — LIVER

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