Regulation of T-helper 17 cell lineage commitment

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper 17 cell lineage commitment pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZAP70, DOCK2, and LCP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 17 cell lineage commitment activity versus ZAP70 in LSCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZAP70 →	+0.580	+0.066	<.001	.001	3	8
GBM	DOCK2 →	+0.643	+0.089	<.001	<.001	3	8
GBM	LCP2 →	+0.642	+0.104	<.001	<.001	3	8
LSCC	LAT_S224 →	+1.019	+0.067	<.001	<.001	3	7
LSCC	SASH3 →	+0.578	+0.098	<.001	<.001	3	7
GBM	WIPF1 →	+0.300	+0.072	.003	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000328 vs ZAP70 — LSCC

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