Regulation of T-helper 17 cell lineage commitment

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper 17 cell lineage commitment pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3D19, APOBEC3G, and IGKV3-7, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 17 cell lineage commitment activity versus SH3D19 in HNSC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SH3D19 →	-0.726	-1.008	<.001	.001	3	3
UCEC	APOBEC3G →	+0.773	+0.200	.004	.001	3	3
UCEC	IGKV3-7 →	+0.823	+0.195	<.001	.002	3	3
LUAD	IGHV3-52 →	+1.145	+0.177	.009	.005	3	3
UCEC	IGHV3-71 →	+0.542	+0.179	<.001	.006	3	3
LUAD	IGHV1OR15-2 →	+2.096	+0.208	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000328 vs SH3D19 — HNSC

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