Regulation of T-helper 17 cell lineage commitment

Across TCGA cell cohorts, RNA activity of the Regulation of T-helper 17 cell lineage commitment pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EP300, GAS2L1, and MBD5, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 17 cell lineage commitment activity versus EP300 in OVARY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EP300 →	+1.544	+0.289	<.001	<.001	3	15
BLOOD_Leukemia	GAS2L1 →	+1.571	+0.158	<.001	<.001	3	12
LIVER	MBD5 →	+0.909	+0.168	<.001	<.001	3	12
URINARY_TRACT	POLDIP3 →	+0.810	+0.143	.003	.003	3	12
LUNG_NSCLC_LUSC	ZBED4 →	+0.777	+0.145	.001	.005	3	12
SOFT_TISSUE	BRD4 →	+0.915	+0.182	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000328 vs EP300 — OVARY

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