Positive regulation of T-helper 17 cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 17 cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP25, ARHGAP25_S363, and PSTPIP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 17 cell differentiation activity versus ARHGAP25 in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP25 →	+0.512	+0.054	<.001	<.001	3	7
CCRCC	ARHGAP25_S363 →	+0.573	+0.081	.001	<.001	3	7
GBM	PSTPIP2 →	+0.561	+0.078	<.001	<.001	3	7
BRCA	SERPINB9 →	+0.631	+0.063	<.001	<.001	3	6
GBM	AIF1 →	+0.713	+0.091	<.001	<.001	3	6
BRCA	LCP2 →	+0.584	+0.058	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000321 vs ARHGAP25 — BRCA

Explore this scatter interactively →