Positive regulation of T-helper 17 cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 17 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRR, DCST1-AS1, and PATZ1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 17 cell differentiation activity versus SRR in GBM (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SRR →	+0.720	+0.084	.004	.006	3	2
GBM	DCST1-AS1 →	+1.315	+0.128	.009	.009	3	2
GBM	PATZ1 →	+0.694	+0.084	.003	.006	3	1
GBM	GCAT →	+0.833	+0.084	.006	.006	3	1
GBM	CCDC134 →	+0.549	+0.084	.009	.006	3	1
GBM	TAB1 →	+0.987	+0.128	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000321 vs SRR — GBM

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