Positive regulation of T-helper 17 cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of T-helper 17 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPX7, YPEL1, and SPIN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPX7 grouped by Positive regulation of T-helper 17 cell differentiation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GPX7 →	-2.433	-0.662	<.001	.007	3	3
BREAST	YPEL1 →	-0.801	-0.323	<.001	.003	3	3
BREAST	SPIN1 →	-0.607	-0.451	.007	.004	3	3
BREAST	PLPPR3 →	-1.026	-0.305	.002	.006	3	3
BREAST	KSR1 →	-0.847	-0.300	.006	.007	3	3
BREAST	PAPPA →	-0.711	-0.311	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPX7 by Positive regulation of T-helper 17 cell differentiation activity — LIVER

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