Positive regulation of T-helper 17 cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of T-helper 17 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SREK1IP1, KRT17, and TMEM25, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 17 cell differentiation activity versus SREK1IP1 in LUNG_SCLC (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SREK1IP1 →	-0.495	-0.198	.003	.004	3	4
OESOPHAGUS	KRT17 →	+4.161	+0.128	<.001	.009	3	3
BLOOD_Myeloma	TMEM25 →	+2.404	+1.085	.007	.002	3	3
BLOOD_Myeloma	AGPAT5 →	-1.052	-1.455	<.001	<.001	3	3
BLOOD_Myeloma	PDF →	-1.025	-1.080	.009	.003	2	4
BLOOD_Myeloma	VPS13D →	+0.543	+1.073	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000321 vs SREK1IP1 — LUNG_SCLC

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