Regulation of T-helper 17 cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper 17 cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R18_S224, THEMIS2_T593, and JUNB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 17 cell differentiation activity versus PPP1R18_S224 in PDAC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PPP1R18_S224 →	+0.412	+0.034	<.001	<.001	3	7
GBM	THEMIS2_T593 →	+0.670	+0.091	<.001	<.001	3	6
GBM	JUNB →	+0.383	+0.102	<.001	<.001	3	6
GBM	TBC1D1 →	+0.304	+0.071	<.001	<.001	3	5
LUAD	DPYSL3_S522 →	+0.510	+0.049	<.001	<.001	3	5
LUAD	AKAP1 →	-0.269	-0.051	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000319 vs PPP1R18_S224 — PDAC

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