Regulation of T-helper 17 cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper 17 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC18A, METTL7A, and TRBV29-1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 17 cell differentiation activity versus CLEC18A in CCRCC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CLEC18A →	-1.010	-0.304	.003	.007	3	4
CCRCC	METTL7A →	-0.717	-0.435	.003	.003	3	4
BRCA	TRBV29-1 →	-0.960	-0.180	.001	.003	3	4
CCRCC	SPRED3 →	+0.355	+0.295	<.001	<.001	3	4
CCRCC	MAOA →	-0.877	-0.303	.007	.009	3	4
CCRCC	LUCAT1 →	+1.157	+0.263	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000319 vs CLEC18A — CCRCC

Explore this scatter interactively →