Regulation of T-helper 17 cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of T-helper 17 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, SERPINE1, and TNFRSF12A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 17 cell differentiation activity versus LGALS1 in STOMACH (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LGALS1 →	+4.739	+0.524	<.001	.004	3	10
PANCREAS	SERPINE1 →	+3.737	+0.246	<.001	.003	3	7
LUNG_SCLC	TNFRSF12A →	+2.682	+0.240	.001	.002	3	6
LARGE_INTESTINE	MYB →	-1.798	-0.625	<.001	.002	3	6
BLOOD_Lymphoma	PRXL2C →	+1.540	+0.627	<.001	<.001	3	6
BLOOD_Lymphoma	ITGB5 →	+1.159	+0.472	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000319 vs LGALS1 — STOMACH

Explore this scatter interactively →