Positive regulation of T-helper 17 type immune response

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 17 type immune response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPRC, BTK, and CORO1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 17 type immune response activity versus PTPRC in GBM (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTPRC →	+0.769	+0.105	<.001	<.001	3	8
GBM	BTK →	+0.519	+0.100	<.001	<.001	3	8
GBM	CORO1A →	+0.599	+0.106	<.001	<.001	3	8
GBM	DEF6 →	+0.576	+0.089	<.001	<.001	3	8
GBM	INPP5D →	+0.609	+0.072	<.001	<.001	3	8
GBM	PARVG →	+0.616	+0.090	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000318 vs PTPRC — GBM

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