Positive regulation of T-helper 17 type immune response

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 17 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCQ, CTLA4, and JAK3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 17 type immune response activity versus PRKCQ in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKCQ →	+1.302	+0.708	<.001	<.001	3	8
BRCA	CTLA4 →	+1.476	+0.673	<.001	<.001	3	7
BRCA	JAK3 →	+0.966	+0.672	<.001	<.001	3	7
LSCC	GZMK →	+1.242	+0.741	<.001	<.001	3	7
BRCA	CCR5 →	+1.235	+0.953	<.001	<.001	3	7
LSCC	TRAT1 →	+1.095	+0.484	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000318 vs PRKCQ — UCEC

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