Positive regulation of T-helper 17 type immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of T-helper 17 type immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR21, NFKBIZ, and PTGDR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MIR21 grouped by Positive regulation of T-helper 17 type immune response-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MIR21 →	-0.532	-1.792	<.001	.007	3	7
LUNG_SCLC	NFKBIZ →	-0.244	-1.272	.008	.006	3	6
BLOOD_Myeloma	PTGDR →	-0.206	-1.455	.003	.001	3	5
LUNG_NSCLC_LUSC	CARD9 →	-0.373	-1.569	.001	.004	3	5
LUNG_NSCLC_LUSC	CLEC6A →	-0.488	-1.579	<.001	<.001	3	5
KIDNEY	MALT1 →	-0.220	-1.368	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIR21 by Positive regulation of T-helper 17 type immune response activity — SOFT_TISSUE

Explore this box plot interactively →