Positive regulation of T-helper 17 type immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of T-helper 17 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX60, INKA2, and PRDM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDX60 grouped by Positive regulation of T-helper 17 type immune response-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DDX60 →	-1.191	-0.250	.002	.003	2	5
BONE	INKA2 →	+1.288	+0.385	.004	.001	3	4
BLOOD_Leukemia	PRDM2 →	-0.950	-0.410	<.001	<.001	3	3
OESOPHAGUS	RPS24 →	-0.706	-0.308	<.001	.002	3	3
SKIN	PBX4 →	-1.161	-0.230	.004	.004	3	3
SKIN	PIP5KL1 →	-0.527	-0.185	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDX60 by Positive regulation of T-helper 17 type immune response activity — SKIN

Explore this box plot interactively →