Negative regulation of T-helper 17 type immune response

Across TCGA patient cohorts, RNA activity of the Negative regulation of T-helper 17 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMNL1, IL27RA, and FOXP3, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T-helper 17 type immune response activity versus FMNL1 in CHOL (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	FMNL1 →	+1.566	+0.043	<.001	.004	2	28
UVM	IL27RA →	+1.092	+0.060	<.001	<.001	3	27
THYM	FOXP3 →	+1.057	+0.042	<.001	<.001	3	26
DLBC	CSF2RB →	+1.454	+0.094	<.001	<.001	3	26
DLBC	HAPLN3 →	+1.710	+0.121	<.001	<.001	3	26
DLBC	SIRPB2 →	+1.184	+0.083	<.001	.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000317 vs FMNL1 — CHOL

Explore this scatter interactively →