Negative regulation of T-helper 17 type immune response

Across TCGA patient cohorts, RNA activity of the Negative regulation of T-helper 17 type immune response pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HIP1, PTK7, and NASP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T-helper 17 type immune response activity versus HIP1 in UCEC (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HIP1 →	+0.292	+0.077	.006	.004	3	5
HNSC	PTK7 →	+0.371	+0.055	<.001	.001	3	5
BRCA	NASP →	+0.540	+0.051	<.001	<.001	3	4
COAD	THOC5 →	+0.167	+0.030	.003	.004	3	4
COAD	GMPPA →	-0.233	-0.033	.006	.006	3	4
GBM	RSU1 →	+0.358	+0.095	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000317 vs HIP1 — UCEC

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