Negative regulation of T-helper 17 type immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of T-helper 17 type immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2, ASCL2, and LOXL3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL2 grouped by Negative regulation of T-helper 17 type immune response-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IL2 →	-0.247	-1.174	.002	.007	3	10
KIDNEY	ASCL2 →	-0.225	-1.145	.003	.001	2	8
BLOOD_Leukemia	LOXL3 →	-0.332	-1.433	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	EN1 →	-0.213	-1.480	.001	.005	3	5
PANCREAS	SLC22A3 →	-0.174	-1.319	<.001	.001	3	4
LUNG_NSCLC_LUAD	RIMKLB →	-0.205	-0.789	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL2 by Negative regulation of T-helper 17 type immune response activity — OVARY

Explore this box plot interactively →