Negative regulation of T-helper 17 type immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of T-helper 17 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NKAP, ANKRD26, and EPB41L5, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T-helper 17 type immune response activity versus NKAP in BLOOD_Leukemia (Pearson r = -0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKAP →	-0.569	-2.488	.002	.004	2	1
BLOOD_Leukemia	ANKRD26 →	-0.764	-2.452	.004	<.001	2	1
BLOOD_Leukemia	EPB41L5 →	-2.083	-2.452	.002	<.001	2	1
BLOOD_Leukemia	NSUN5 →	-1.104	-2.452	.004	<.001	2	1
BLOOD_Leukemia	DYNC1LI2 →	-1.160	-2.488	.004	.004	2	1
BLOOD_Leukemia	C9orf72 →	-0.850	-2.488	.002	.004	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000317 vs NKAP — BLOOD_Leukemia

Explore this scatter interactively →