Regulation of T-helper 17 type immune response

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper 17 type immune response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYO1F, PPP1R18, and PPP1R18_S368, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 17 type immune response activity versus MYO1F in GBM (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYO1F →	+0.772	+0.106	<.001	<.001	3	8
LSCC	PPP1R18 →	+0.420	+0.081	<.001	<.001	3	8
OV	PPP1R18_S368 →	+0.823	+0.035	.008	.005	3	8
GBM	WIPF1 →	+0.329	+0.083	<.001	<.001	3	8
GBM	PSTPIP1 →	+0.511	+0.086	<.001	<.001	3	8
UCEC	SLC25A1 →	-0.525	-0.072	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000316 vs MYO1F — GBM

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