Regulation of T-helper 17 type immune response

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper 17 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL21R, PRKCQ-AS1, and CD86, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 17 type immune response activity versus IL21R in CCRCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	IL21R →	+0.671	+0.374	.002	.002	3	6
UCEC	PRKCQ-AS1 →	+0.789	+0.209	<.001	<.001	3	6
HNSC	CD86 →	+0.630	+0.201	.001	.009	2	6
CCRCC	SAMSN1 →	+0.720	+0.365	.001	.005	3	5
UCEC	CTLA4 →	+1.238	+0.247	<.001	<.001	3	5
UCEC	PRKCQ →	+1.136	+0.212	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000316 vs IL21R — CCRCC

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