Regulation of T-helper 17 type immune response

Across TCGA cell cohorts, RNA activity of the Regulation of T-helper 17 type immune response pathway is significantly associated with the protein abundance of multiple proteins, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3G, LGALS1, and SFXN3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 17 type immune response activity versus EIF3G in CNS (Pearson r = -0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EIF3G →	-0.981	-0.156	.002	.001	3	8
LARGE_INTESTINE	LGALS1 →	+4.560	+0.841	<.001	<.001	3	7
BLOOD_Leukemia	SFXN3 →	+1.764	+0.522	.001	.005	3	7
BREAST	OPA1 →	+0.872	+0.208	<.001	.001	2	8
CNS	CCT4 →	-1.038	-0.161	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	TRMT112 →	-1.439	-0.334	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000316 vs EIF3G — CNS

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