Regulation of AMPA receptor activity

Across TCGA patient cohorts, RNA activity of the Regulation of AMPA receptor activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CALR, DNAJB11, and EEF1A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of AMPA receptor activity activity versus CALR in BRCA (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CALR →	-0.239	-0.027	<.001	<.001	3	4
BRCA	DNAJB11 →	-0.256	-0.031	.003	.002	3	4
GBM	EEF1A2 →	+0.431	+0.059	<.001	<.001	3	4
HNSC	BCL3_S374 →	-0.426	-0.073	.001	.002	3	4
UCEC	LIG1_S66 →	-0.494	-0.066	.005	<.001	3	4
BRCA	HDGFL3 →	+0.557	+0.041	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000311 vs CALR — BRCA

Explore this scatter interactively →