Regulation of AMPA receptor activity

Across TCGA patient cohorts, RNA activity of the Regulation of AMPA receptor activity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECSCR, CLIC5, and EMCN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of AMPA receptor activity activity versus ECSCR in CCRCC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ECSCR →	+0.706	+0.575	<.001	<.001	3	6
LSCC	CLIC5 →	+0.751	+0.346	<.001	<.001	3	6
CCRCC	EMCN →	+1.298	+0.620	<.001	<.001	3	6
CCRCC	HRC →	+0.736	+0.494	<.001	<.001	3	6
LSCC	P2RY8 →	+0.778	+0.419	<.001	<.001	3	6
HNSC	GIMAP1 →	+0.643	+0.311	.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000311 vs ECSCR — CCRCC

Explore this scatter interactively →