Regulation of NMDA receptor activity

Across TCGA cell cohorts, RNA activity of the Regulation of NMDA receptor activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAMBPL1, DUSP18, and CCN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STAMBPL1 grouped by Regulation of NMDA receptor activity-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	STAMBPL1 →	-2.672	-1.639	<.001	.002	3	4
LUNG_SCLC	DUSP18 →	+1.037	+1.474	.001	<.001	3	4
SOFT_TISSUE	CCN1 →	-3.641	-1.071	<.001	.008	3	4
BLOOD_Lymphoma	SH2D6 →	+0.580	+1.524	.002	<.001	3	4
BLOOD_Lymphoma	FAM227B →	+0.585	+1.384	.004	.004	3	4
BONE	NISCH →	+1.216	+1.842	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STAMBPL1 by Regulation of NMDA receptor activity activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →