Negative regulation of synaptic vesicle exocytosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of synaptic vesicle exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRBP1_T275, AHNAK_S5031, and RPL18A_S123, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of synaptic vesicle exocytosis activity versus RRBP1_T275 in LUAD (Pearson r = -0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RRBP1_T275 →	-0.460	-0.044	.005	.002	3	4
CCRCC	AHNAK_S5031 →	-0.524	-0.044	.003	.001	3	4
LSCC	RPL18A_S123 →	-0.297	-0.043	.003	.003	3	4
LSCC	DOHH →	-0.120	-0.036	<.001	.001	3	4
HNSC	GEM_S23 →	+0.522	+0.100	.004	.002	3	4
COAD	TRAF3IP2_S383 →	-0.515	-0.076	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000301 vs RRBP1_T275 — LUAD

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