Negative regulation of synaptic vesicle exocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of synaptic vesicle exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMR1, CCNQ, and VMA21, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of synaptic vesicle exocytosis activity versus FMR1 in LARGE_INTESTINE (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FMR1 →	+1.167	+0.588	<.001	.001	3	8
BLOOD_Lymphoma	CCNQ →	+0.504	+0.628	.006	.003	3	6
LUNG_SCLC	VMA21 →	+0.825	+1.125	<.001	<.001	3	5
BREAST	MECP2 →	+0.855	+0.864	.002	.003	3	5
BREAST	FAM122B →	+1.053	+0.955	.002	<.001	3	5
LUNG_NSCLC_LUAD	FUNDC2 →	+0.660	+0.247	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000301 vs FMR1 — LARGE_INTESTINE

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