Regulation of synaptic vesicle exocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic vesicle exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YAP1, FLNA, and FLNA_S1338, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle exocytosis activity versus YAP1 in BRCA (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	YAP1 →	-0.413	-0.034	<.001	.001	3	6
GBM	FLNA →	-0.470	-0.115	<.001	<.001	3	6
BRCA	FLNA_S1338 →	-0.673	-0.034	<.001	<.001	3	6
COAD	PDLIM4 →	-0.541	-0.034	<.001	<.001	3	6
BRCA	PHLDB1 →	-0.497	-0.041	<.001	<.001	3	6
BRCA	RIN2_S783 →	-0.670	-0.043	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000300 vs YAP1 — BRCA

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